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Behind every great day is a great night at the Comfort Inn and Suites Tuscumbia-Muscle Shoals hotel in Tuscumbia, AL. Nearby destinations include Tuscumbia Railroad Depot Museum, Shiloh National Military Park, University of North Alabama and the Alabama Music Hall of Fame. Enjoy amenities like free hot breakfast, free WiFi, guest laundry facilities, a newsstand and a fitness center. Rooms include a flat-screen TV, refrigerator, microwave, hair dryer and a coffee maker. Also, earn rewards including free nights and gift cards with our Choice Privileges Rewards program.