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The all-suites Comfort Suites Greenville South hotel in Piedmont, SC near Downtown Greenville has all the essentials you need to stay on your game and be your best. We are located just off Interstates 85 and 185, the Toll Expressway to Simpsonville, SC near GSP International. Our central location makes it easy to visit Greenville, Anderson, Piedmont and Easley, SC. Start or end your day in our fitness center or indoor heated saline pool. Your suite provides a large open floor plan, seating area, free WiFi, coffee maker, microwave and mini-refrigerator. Earn rewards with every stay with our Choice Privileges rewards program. Rested, set, go - book now. No Pets Allowed.