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Get rested, set and ready for anything when you stay at our Comfort Inn and Suites hotel in Santee, SC. We are close to Lake Marion, Santee Wildlife Refuge, Palmetto Trail and Santee Welcome Center. Each guest can enjoy our free breakfast, free WiFi, exercise room, seasonal outdoor pool and laundry facility. Unwind in one of our guest rooms, all of which feature a flat-screen TV, coffee maker and hair dryer. Sign up today for our Choice Privileges program and start earning rewards points with your next stay. *Some amenities may require an additional cost. This hotel does not accept local guests. All hotel guests must have ID showing a residence at least 45 miles away from the hotel in order to check-in.