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Stay Your Way at the Hampton Inn and Suites Houston/League City TX. Just 25 miles south of Downtown Houston and 20 miles North of Galveston Island we are located off of Interstate 45. our hotel*s location is convenient for all traveler. Whether you*re here for business or pleasure the Hampton Inn - Suites Houston/League City has much to offer. Regardless of your reason for staying with us you*ll be able to enjoy our fantastic amenities like the refreshing outdoor pool and whirlpool the well-equipped fitness center and our daily free hot breakfast buffet. Make your reservations today to take advantage of everything we have to offer.