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21c Museum Hotel Louisville is located at 700 West Main Street in historic downtown Louisville in the heart of Museum Row. Within walking distance of downtown attractions dining entertainment and major corporations. SDF-Louisville International Airport- 8 mile S
Nestled in historic downtown Louisville on Museum Row 21c is a 91-room boutique hotel contemporary art museum cultural civic center and the award-winning restaurant Proof on Main. As the most unique hotel in Louisville KY we pride ourselves on offering one-of-a-kind experiences for our guests who are visiting the area for business and leisure alike.