- 67 Available Hotels Near I-64 and US-40
- Rates Starting at just $52.99
- 36 Chains To Choose From
- Last Minute Inventory!
Looking for a hotel near I-64 and US-40 in Saint Charles, MO? Hotels-Rates has you covered with everything you need to know about hotels and lodging near this exit and elsewhere in Saint Charles. Whether you are traveling on vacation or for business, we have guides on all the points of interest, attractions, and venues in Saint Charles. Driving to tour the campus? Missouri Baptist University, Logan College and Chiropractic, Maryville University and Lindenwood University are quite close to the exit, with Missouri Baptist University being the closest. Trying to find hotels close to Family Arena? If you’re into sports, you will be excited to know that the Family Arena is a short drive away.