- 52 Available Hotels Near I-81 and I-581
- Rates Starting at just $43.26
- 28 Chains To Choose From
- Last Minute Inventory!
Searching for lodging at I-81 and I-581 in Roanoke, VA? Hotels-Rates has got you covered with all you want to know about hotels and lodging around this intersection and elsewhere in Roanoke. Whether you are traveling for pleasure or work, we have info on all the things to do, attractions and accomodations in Roanoke. Driving to tour the campus? Hollins University, Jefferson College of Health Sciences and Roanoke College are very close to the exit, with Hollins University being the closest.